Wild Alaskan Fish Oil | Alixir Life

Wild Alaskan Fish Oil

The Essential Fatty Acids

  • Helps circulation and heart
  • Supports pregnancy and young children
  • Reduces some types of joint pain
  • Supports eye health
  • May aid long-term brain function

OVERVIEW

Fish Oil contains Omega 3 fatty acids (EPA and DHA to be specific) that are important for our heart, brain, joints and eyes, but many of us don’t get enough of it in our diet. Studies suggest that people who consume Omega 3 oil on a regular basis have lower rates of heart disease than those who do not.[1] [2] [3]  Omega 3 fatty acids make up a large portion of our brain and are important for normal brain function.[4] They are also a critical fatty acid required for the growth and development of a baby[5] so are recommended for pregnant or lactating women. Additionally, Omega 3 can act as an anti-inflammatory and appears to alleviate the pain in rheumatoid arthritis and work-related joint pain. It may also reduce the risk of age-related macular degeneration in the eyes and guard against dryness.

Our Omega 3 fatty acid is sourced from 100% Wild Alaskan Salmon Fish. Wild Salmon has higher concentrations of Omega 3 fatty acids than farmed salmon and significantly lower or non-existent levels of antibiotics, PCB and dioxin. The extraction process is environmentally friendly since the oil is extracted from already-harvested salmon, using part of the fish that would be otherwise wasted. Our supplier tests the salmon regularly for chemical and heavy metal residue to ensure quality and safety.

Product Type: 2 Softgels
Dosage: 2000mg


Ingredients

Wild Alaskan Salmon Oil (Omega-3 Fatty Acids, Eicosapentaenoic Acid (EPA), Docosahexaenoic Acid (DHA), Astaxanthin (naturally occurring – wild Alaskan salmon oil), Vitamin D (naturally occurring – wild Alaskan salmon oil)). Other ingredients: softgel (gelatin, glycerin, purified water, vitamin E).

does not contain

milk, eggs, shellfish, tree nuts, wheat, soybeans, artificial colours and preservatives

summary of research

  • Helps circulation and heart

    Studies show that people who consume Omega 3 oil regularly have lower rates of heart disease.[6] [7] [8] This may be due to Omega 3 fatty acid’s increasing  good cholesterol, lowering triglyceride levels (a high level increases the risk of heart disease), managing blood pressure, and preventing plaque buildup (leading to clogged arteries and strokes).[9] [10] [11] [12] This is why the US Department of Health and Human Services and the American Heart Association advise people to consume two servings of fish per week in order to get sufficient Omega 3 fatty acids.[13] [14] Where this is not possible, people should consider taking fish oil supplements.

     

    Research Score: Very Strong

  • May aid long-term brain function

    Whilst studies are mixed on Omega 3 and mental health, there is promising research to suggest that it may improve memory, reduce the symptoms of ADHD in children[15], increase brain volume, and slow cognitive decline in the elderly.[16] [17] [18]

     

    Illustrative Studies

     

    Memory

     

    In a double-blind, placebo-controlled and randomized study, 485 people were given 900mg of Omega 3 or a placebo before doing paired associate learning (PAL), memory and visuospatial learning tests. The Omega 3 taking group performed better on the PAL test and had better immediate and delayed verbal memorization scores, but there was no improvement in working memory or executive function.[19]

     

    ADHD

     

    In a randomised controlled study on children with ADHD, one group took EPA (an Omega-3 fatty acid) while the other took a placebo for 15 weeks. The children’s performance was assessed by teachers and their parents. The EPA taking group had better behavior scores from their teachers, but not from their parents. Children who started with lower EPA in their bloodstream responded better to treatment than those with higher EPA concentrations.[20]

     

    Brain Volume

     

    One study examined the red blood cell fatty acid levels of over 1500 people who were free from dementia. It found that people in the lowest quartile of red blood cell DHA (an Omega-3 fatty acid) levels had greater white matter hyper intensity (lesions in the brain) and smaller brain volume. It also found that those with lower DHA levels did not perform as well on abstract thinking, executive function and visual memory as those with higher levels.[21]

     

    Another different study concluded that those with higher DHA levels did better on nonverbal reasoning, working memory and vocabulary in addition to being able to better mentally adapt to changes. However, it also made clear that EPA levels did not affect cognitive performance.[22]

     

    Cognitive decline in elderly and Alzheimer’s disease

     

    In 2005, a study assessed the effect that Omega 3 had upon cognitive decline in those aged 65 and above. It found that fish consumption may be associated with slower cognitive decline with age.[23]

     

    Later in 2008, a second study examined the impact of Omega 3 on people with Alzheimer’s and mild cognitive impairment. It concluded that 1800 mg of Omega 3 and higher intake of EPA led to better cognitive performance for those who had mild cognitive impairment, but it found no affect upon those with Alzheimer’s.[24]

     

    Research Score: Strong

  • Supports pregnancy and young children

    Omega 3 supplementation in breastfeeding and pregnant moms is linked to improved infant retina and brain development[25] [26]. That is why the United States Food and Drug Administration recommends pregnant women and young children should eat more fish.[27]

     

    Illustrative Studies

     

    In a randomised and controlled 1993 trial, infants were split into two groups. One was fed fish oil and the other was not. The study concluded that visual ability was positively related to DHA (an Omega-3 fatty acid) supplementation. [28] Additionally, a 2013 review of more recent studies concluded that “providing larger amounts of DHA supplements, especially to the smallest infants, is associated with better neurologic outcomes in early life”.[29]

     

    There is also promising evidence that Omega 3 can lengthen the reproductive window for women of normal weight, although not in women with BMIs greater than 30.[30] A 2016 clinical trial examined whether supplementation of Omega 3 could alter reproductive hormones in reproductive-age women and concluded  that supplementation does extend reproductive lifespan, although further testing on women with diminished ovarian reserve who were attempting to delay ovarian aging would be needed.[31]

     

    Research Score: Strong

  • Reduces some types of joint pain

    Studies on Omega 3 show it can alleviate joint pain as it is anti-inflammatory on cartilage.[32] One study found it can alleviate rheumatoid arthritis and work-related joint pain (not disease related pain like osteoarthritis or rheumatism).[33]

     

    A second study lasted 12 months. It was double-blind and placebo-controlled and found that people taking 2,600mg of Omega 3 per day had less joint pain than those on the placebo. Additionally, participants had to use less antirheumatic medicine after taking fish oil supplements. [34]

     

    Research Score: Strong

  • Supports eye Health

    Dry Eye

    Several studies indicate that fish oil alleviates dry eye symptoms. [35] One 2016 study found that fish oil (which contains Omega-3 fatty acids) decreased the symptoms even after patients had just had cataract surgery. [36] Another study examined people who look at computer screens for over 3 hours per day and also found that fish oil alleviated dry eye and decreased tear evaporation.[37] In fact, the American Academy of Ophthalmology found in a clinical study that Omega 3 decreased the symptoms of dry eye, increased the rate in tear secretion and decreased the rate of tear evaporation.[38]

     

    Age-related Macular Degeneration

     

    A 2006 study examined genetic and environmental risk factors for age-related macular degeneration. It surveyed 681 twins through food diaries, risk-factor questionnaires and eye examinations. Smokers had almost double the risk of macular degeneration compared to non-smokers, and increased intake of fish reduced the risk of macular degeneration.[39]

     

    Retina Protection

    While there have been many positive studies on the near total protection of the retina in rats after taking fish oil[40] [41] [42] [43] [44] [45], there are only some studies on its effect on humans.[46] [47] Therefore, it is most likely that humans will experience the same level of protection to their retinas, although further research is needed.

     

    Research Score: Strong

  • Reduces depression in majorly depressed persons

    For people diagnosed with major depressive disorder, fish oil can significantly reduce symptoms to a level similar to some prescription drugs like fluoxetine. However, it is not clear in can reduce the symptoms in those who have not been diagnosed with major depressive disorder. There needs to be more studies on the effect of fish oil upon people who are minorly depressed.[48]

     

    Research Score: Promising

  • References

    1. He K, Song Y, Daviglus ML, et al. Accumulated evidence on fish consumption and coronary heart disease mortality: a meta-analysis of cohort studies. Circulation. 2004;109(22):2705-11.

     

    2. Kromhout D, Bosschieter EB, De lezenne coulander C. The inverse relation between fish consumption and 20-year mortality from coronary heart disease. N Engl J Med. 1985;312(19):1205-9.

     

    3. Chowdhury, R., Stevens, S., Gorman, D., Pan, A., Warnakula, S., Chowdhury, S., Ward, H., Johnson, L., Crowe, F., Hu, F. and Franco, O. (2018). Association between fish consumption, long chain omega 3 fatty acids, and risk of cerebrovascular disease: systematic review and meta-analysis. [online] PubMed Health. Available at:

    https://tinyurl.com/y596unn9

    [Accessed 21 Jul. 2018].

     

    4. Bazinet RP, Layé S. Polyunsaturated fatty acids and their metabolites in brain function and disease. Nat Rev Neurosci. 2014;15(12):771-85.

     

    5. Simopoulos AP. Omega-3 fatty acids in health and disease and in growth and development. Am J Clin Nutr. 1991;54(3):438-63.

     

    7. He K, Song Y, Daviglus ML, et al. Accumulated evidence on fish consumption and coronary heart disease mortality: a meta-analysis of cohort studies. Circulation. 2004;109(22):2705-11.

     

    8. Chowdhury, R., Stevens, S., Gorman, D., Pan, A., Warnakula, S., Chowdhury, S., Ward, H., Johnson, L., Crowe, F., Hu, F. and Franco, O. (2018). Association between fish consumption, long chain omega 3 fatty acids, and risk of cerebrovascular disease: systematic review and meta-analysis. [online] PubMed Health. Available at:

    https://tinyurl.com/y596unn9

    [Accessed 21 Jul. 2018].

     

    9. Warner JG, Ullrich IH, Albrink MJ, Yeater RA. Combined effects of aerobic exercise and omega-3 fatty acids in hyperlipidemic persons. Med Sci Sports Exerc. 1989;21(5):498-505.

     

    10. Oelrich B, Dewell A, Gardner CD. Effect of fish oil supplementation on serum triglycerides, LDL cholesterol and LDL subfractions in hypertriglyceridemic adults. Nutr Metab Cardiovasc Dis. 2013;23(4):350-7.

     

    11. Minihane AM, Armah CK, Miles EA, et al. Consumption of Fish Oil Providing Amounts of Eicosapentaenoic Acid and Docosahexaenoic Acid That Can Be Obtained from the Diet Reduces Blood Pressure in Adults with Systolic Hypertension: A Retrospective Analysis. J Nutr. 2016;146(3):516-23.

     

    12. Din JN, Archer RM, Harding SA, et al. Effect of ?-3 fatty acid supplementation on endothelial function, endogenous fibrinolysis and platelet activation in male cigarette smokers. Heart. 2013;99(3):168-74.

     

    13. US Department of Health and Human Services and US Department of Agriculture. 2015–2020 Dietary Guidelines for Americans. 8th ed. Washington, DC: US Government Printing Office; 2015, AHA SCIENCE ADVISORY, ‘Seafood Long-Chain n-3 Polyunsaturated Fatty Acids and Cardiovascular Disease A Science Advisory From the American Heart Association’, Circulation. 2018;138:e35–e47,

    https://tinyurl.com/yxskkcz7

    (accessed 20 Feb 2019)

     

    14. Fish and Omega-3 Fatty Acids, American Heart Association®, American Heart Association®, 2015

     

    15.

    https://tinyurl.com/y3dq2ae5

     

    16.

    https://tinyurl.com/y5tnxwmq

     

    17. Morris MC, Evans DA, Tangney CC, Bienias JL, Wilson RS. Fish consumption and cognitive decline with age in a large community study. Arch Neurol. 2005;62(12):1849-53.

     

    18. Thomas J, Thomas CJ, Radcliffe J, Itsiopoulos C. Omega-3 Fatty Acids in Early Prevention of Inflammatory Neurodegenerative Disease: A Focus on Alzheimer’s Disease. BioMed Research International. 2015;2015:172801. doi:10.1155/2015/172801.

     

    19. Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline.

    Yurko-Mauro K, McCarthy D, Rom D, Nelson EB, Ryan AS, Blackwell A, Salem N Jr, Stedman M; MIDAS Investigators., Alzheimer's & dementia: the journal of the alzheimer's association., 2010

     

    20. EPA supplementation improves teacher-rated behaviour and oppositional symptoms in children with ADHD., Gustafsson PA, Birberg-Thornberg U, Duchén K, Landgren M, Malmberg K, Pelling H, Strandvik B, Karlsson T., Acta Paediatrica, 2010

     

    21. Red blood cell ω-3 fatty acid levels and markers of accelerated brain aging.

    Tan ZS, Harris WS, Beiser AS, Au R, Himali JJ, Debette S, Pikula A, Decarli C, Wolf PA, Vasan RS, Robins SJ, Seshadri S., Neurology, 2012

     

    22. Serum phospholipid docosahexaenonic acid is associated with cognitive functioning during middle adulthood., Muldoon MF, Ryan CM, Sheu L, Yao JK, Conklin SM, Manuck SB., The journal of nutrition, 2010

     

    23. Morris MC, Evans DA, Tangney CC, Bienias JL, Wilson RS. Fish consumption and cognitive decline with age in a large community study. Arch Neurol. 2005;62(12):1849-53.

     

    24. The effects of omega-3 fatty acids monotherapy in Alzheimer's disease and mild cognitive impairment: a preliminary randomized double-blind placebo-controlled study., Chiu CC, Su KP, Cheng TC, Liu HC, Chang CJ, Dewey ME, Stewart R, Huang SY., Progress in neuro-psychopharmacology and biological psychiatry, 2008

     

    25. Simopoulos AP. Omega-3 fatty acids in health and disease and in growth and development. Am J Clin Nutr. 1991;54(3):438-63.

     

    26. Eilander A, Hundscheid DC, Osendarp SJ, Transler C, Zock PL. Effects of n-3 long chain polyunsaturated fatty acid supplementation on visual and cognitive development throughout childhood: a review of human studies. Prostaglandins Leukot Essent Fatty Acids. 2007;76(4):189-203.

     

    27. ‘New Advice: Pregnant Women and Young Children Should Eat More Fish’, Federal Drug Administration, FDA News Release 2014,

    https://tinyurl.com/y3mwqxk2

    (accessed March 7 2019)

     

    28. Carlson SE, Werkman SH, Rhodes PG, Tolley EA. Visual-acuity development in healthy preterm infants: effect of marine-oil supplementation. Am J Clin Nutr. 1993;58(1):35-42.

     

    29. Lapillonne A, Groh-Wargo S, Gonzalez CH, Uauy R., Lipid needs of preterm infants: updated recommendations., J Pediatr. 2013 Mar;162(3 Suppl):S37-47

     

    30. Nehra D, Le HD, Fallon EM, Carlson SJ, Woods D, White YA, Pan AH, Guo L, Rodig SJ, Tilly JL, Rueda BR, Puder M., Prolonging the female reproductive lifespan and improving egg quality with dietary omega-3 fatty acids., Aging Cell. 2012 Dec;11(6):1046-54

     

    31. Al-Safi ZA, Liu H, Carlson NE, Chosich J, Harris M, Bradford AP, Robledo C, Eckel RH, Polotsky AJ., Omega-3 Fatty Acid Supplementation Lowers Serum FSH in Normal Weight But Not Obese Women., J Clin Endocrinol Metab. 2016 Jan;101(1):324-33

     

    32. n-3 fatty acids specifically modulate catabolic factors involved in articular cartilage degradation.

    Curtis CL, Hughes CE, Flannery CR, Little CB, Harwood JL, Caterson B., The Journal of Biological Chemistry, 2000

    Goldberg RJ, Katz J. A meta-analysis of the analgesic effects of omega-3 polyunsaturated fatty acid supplementation for inflammatory joint pain . Pain. (2007),

    https://tinyurl.com/yxkmmbeg

    (accessed 20 Feb 2019)

     

    34. Long-term effect of omega-3 fatty acid supplementation in active rheumatoid arthritis. A 12-month, double-blind, controlled study., Geusens P, Wouters C, Nijs J, Jiang Y, Dequeker J., Arthritis and Rheumatism, 1994

     

    35. A randomized controlled trial of omega-3 fatty acids in dry eye syndrome

    Bhargava R, Kumar P, Kumar M, Mehra N and Mishra A, International journal of ophthalmology, 2013

     

    36. Effects of adjuvant omega-3 fatty acid supplementation on dry eye syndrome following cataract surgery: A randomized clinical trial, Mohammadpour M, Mehrabi S, Hassanpoor N, Mirshahi R., Journal of Current Ophthalmology, 2016

     

    37. Oral omega-3 fatty acids treatment in computer vision syndrome related dry eye.

    Bhargava R, Kumar P, Phogat H, Kaur A, Kumar M., Contact lens & anterior eye, 2015

     

    38. Short-term Consumption of Oral Omega-3 and Dry Eye Syndrome

    Kangari H, Eftekhari MH, Sardari S, Hashemi H, Salamzadeh J, Ghassemi-Broumand M, Khabazkhoob M., Ophthalmology, 2013

    39. Cigarette smoking, fish consumption, omega-3 fatty acid intake, and associations with age-related macular degeneration: the US Twin Study of Age-Related Macular Degeneration.

    Seddon JM, George S, Rosner B., JAMA Ophthalmology, 2006

     

    40. SanGiovanni JP, Chew EY. The role of omega-3 long-chain polyunsaturated fatty acids in health and disease of the retina. Prog Retin Eye Res. (2005)

     

    41. Bazan NG. Neuroprotectin D1 (NPD1): a DHA-derived mediator that protects brain and retina against cell injury-induced oxidative stress. Brain Pathol. (2005)

     

    42. Futterman S, Kupfer C. The fatty acid composition of the retinal vasculature of normal and diabetic human eyes. Invest Ophthalmol. (1968)

     

    43. Tikhonenko M, et al. N-3 polyunsaturated Fatty acids prevent diabetic retinopathy by inhibition of retinal vascular damage and enhanced endothelial progenitor cell reparative function. PLoS One. (2013)

     

    44. Kang JX, et al. Transgenic mice: fat-1 mice convert n-6 to n-3 fatty acids. Nature. (2004)

     

    45. Connor KM, et al. Increased dietary intake of omega-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis. Nat Med. (2007)

     

    46. Opreanu M, et al. The unconventional role of acid sphingomyelinase in regulation of retinal microangiopathy in diabetic human and animal models. Diabetes. (2011)

     

    47. Decsi T, et al. Polyunsaturated fatty acids in plasma and erythrocyte membrane lipids of diabetic children. Prostaglandins Leukot Essent Fatty Acids. (2002)

     

    48.

    https://tinyurl.com/y49svsne